Sulf1 ovary
WebSULF1 controls the sulfation status of heparan sulfate proteoglycans and plays a role in tumor growth and metastasis, while its role is unexplored in UC. To first elucidate the … Web1 Feb 2024 · SULF1 transcript is downregulated in ovarian, breast, kidney, pancreatic and hepatocellular cancer cell lines and primary ovarian tumors [ 16 ]. The lower expression level of SULF1 transcript was also observed in lung cancer cell …
Sulf1 ovary
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The first signs of Sulf1 dysregulation were found in ovarian cancer. The expression of Sulf1 mRNA was found to be downregulated or absent in a majority of ovarian cancer specimens. [18] The same investigators also found lowered mRNA expression in breast, pancreatic, and hepatic malignant cell lines. [18] See more Sulfatase 1, also known as SULF1, is an enzyme which in humans is encoded by the SULF1 gene. Heparan sulfate proteoglycans (HSPGs) act as co-receptors for numerous heparin-binding growth … See more Heparan sulfate proteoglycans (HSPGs) are widely expressed throughout most tissues of nearly all multicellular species. The function of HSPGs extends beyond providing an extracellular matrix (ECM) structure and scaffold for cells. They are integral regulators … See more HS enzymatic specificity of QSulf1 was first analyzed. QSulf1 enzymatic specificity on 6-O sulfates was linked to the trisulfated disaccharides (HexA,2SGlcNS,6S) … See more In addition to cancer, Sulf1 and Sulf2 were studied with respect to normal development including neural, muscle, vasculogenesis and skeletal development. Recently, much of what is known was from studies on Sulf1/2 knockout mice. Skeletal Development See more Before the cloning and characterization of Sulf1 and Sulf2, HS composition was thought to be unchanging after localization to the … See more Sulf1 and Sulf2 are new members of a superfamily of arylsulfatases, being closely related to arylsulfatase A, B (ARSA; ARSB) and glucosamine 6-sulfatase (G6S). The x-ray crystal structure … See more The next section gives a detailed description of Sulf1 and Sulf2’s involvement in cancer. Much of what is known about signaling pathways mediated by Sulfs has been … See more WebProtein structure - SULF1 - The Human Protein Atlas DISEASE SULF1 PROTEIN STRUCTURE ANTIBODIES AND VALIDATION Protein structures PROTEIN STRUCTUREi Predicted Your browser/graphics card does not seem to support WebGL. Find out how to get it here. Description: Structure prediction from Alphafold project. Structure version 2
WebSULF1. On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). … Web1 Mar 2003 · Expressed at highest levels in testis, stomach, skeletal muscle, lung, kidney, pancreas, small intestine and colon. It is also detected in normal ovarian surface epithelial …
Web7 Jan 2011 · In ovarian cancer, decreased expression of SULF1 and its correlation with decreased sensitivity to cisplatin (a standard chemotherapeutic agent) were also reported [12,15]. Loss of heterozygosity or hypermethylation of the promoter region has been suggested as potential mechanisms for SULF1 down-regulation in ovarian cancer [ 14 ]. http://www.cancerindex.org/geneweb/SULF1.htm
WebOvarian cancer is the leading cause of death from gynecologic cancers, but platinum resistance remains a major obstacle in the chemotherapy of ovarian cancer. This study aims to examine the role of polymorphisms in sulfatase 1 (SULF1) in platinum resistance and
Web1 Apr 2024 · Sulf1 is a TGF-beta1-responsive gene both in vitro and in vivo and may function as a negative regulator of TGF-beta1-induced fibrogenesis modulates signaling … shanghai us consulate addressWeb1 Mar 2012 · SULF1 is an endosulfatase able to cleave specific 6-O sulfate groups within the heparan chains. This action can modulate signaling processes, modulating the effects of … polyester elastic waist skirtsWeb1 Jan 2024 · Objective. Early detection of platinum resistance for ovarian cancer treatment remains challenging. This study aims to develop a machine learning model incorporating genomic data such as Single-Nucleotide Polymorphisms (SNPs) of Human Sulfatase 1 (SULF1) with a CT radiomic model based on pre-treatment CT images, to predict platinum … polyester elastic webbingWeb7 Jan 2011 · SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1expression has been reported to be decreased in various cancers, including ovarian cancer. polyester fabric crossword clueWebThis study aims to examine the role of polymorphisms in sulfatase 1 (SULF1) in platinum resistance and survival in advanced epithelial ovarian cancer (EOC) patients. We … shanghai us embassy visa appointmentWeb11 Apr 2024 · When we perturbed morphogen feedback loops by introducing a Sulf1 or dally mutation, wdp mutation resulted in severe morphological defects, including abnormal patterning of wing blade and hinge structures, egg retention in the ovary and a wing posture abnormality. Our results implicate Wdp as a novel player of the morphogen feedback … polyester embroidery machine threadWeb15 Jan 2024 · Sulf1 inhibits ISC division during normal homeostasis. ... In addition, it has been shown that JAK-STAT signaling is regulated by HSPGs in the ovary (Hayashi et al., 2012). Therefore, it is reasonable to speculate that Sulf1 also regulates this pathway. polyester fabric chemistry