WebFurther, 14-3-3ζ overexpression prevented phospho-beclin 1 S295 from degradation and enhanced its binding to VPS34, whilst its knockdown accelerated the degradation. Additionally, 14-3-3ζ enhanced the chemoresistance of HCC cells to cis-diammined dichloridoplatium by activating autophagy. WebJul 2, 2015 · Multiple pathways that traffic material to the lysosomes require the lipid kinase VPS34, the only known class III phosphoinositide 3-kinase (Backer, 2008; Raiborg et al, 2013 ). VPS34 catalyses the phosphorylation of phosphatidylinositol (PI) at the three position of the inositol ring to produce phosphatidylinositol 3-phosphate (PI (3)P).

Phospho-VPS34 (Ser244, Ser249) Polyclonal Antibody

WebJan 17, 2013 · Anti-phospho-Beclin1 S91/S94 and Vps34 T163/S165 antibodies were generated by immunizing rabbits with the corresponding phosphopeptides, and the phosphospecific antibodies were affinity purified (Cell Signaling Technology). The details on other antibodies and the reagents can be found in the Extended Experimental Procedures. WebAs a control for successful Lapatinib treatment, we also checked levels of Phospho-Her2 (Figure 1a). ... It was dissolved in DMSO and stored at −20 °C. The VPS34 inhibitor (VPS34-IN1) was purchased from Selleckhchem (1383716-33-3), diluted in DMSO, and stored at −20 °C. 4.2. Cell Culture and Generation of Resistant OE19 Cells. mitsubishi golf diamana s+ 60g

Products > Proteins/Peptides > Human > Full-length - Product List

WebApr 11, 2024 · Upon autophagy induction, the ULK1 complex translocates to autophagy initiation sites and regulates the recruitment of a second kinase complex, the vacuolar protein sorting 34 (VPS34) complex consisting of VPS34, as well as Beclin-1, VPS15, and ATG14L, which promotes the formation of autophagic vesicles ( 26, 27 ). WebGeneral description. Vacuolar protein sorting 34 (VPS34), also known as phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3), is encoded by the gene mapped to human chromosome 18q12.3. The encoded protein belongs to the phosphoinositide (PI)-3-kinase family. [ 1] VPS34 is widely expressed in all tissues of … WebMar 25, 2024 · Phospho-VPS34 (Ser164) Polyclonal Antibody Catalog # : PA5-12829 Quantity : 400 µL Pricing : US 417 Clonality : Polyclonal Purity : Antigen affinity … mitsubishi golf driver shaft comparisons