WitrynaNaphthoate synthase (menB) is a key enzyme required for the synthesis of menaquinone, which plays a crucial role in anaerobic electron transport, ultimately … Witryna1,4-dihydroxy-2-naphthoyl-CoA synthase Synonyms. 4.1.3.36; DHNA-CoA synthase; Gene Name menB ... Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms. Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1199-206. Epub 2005 Aug 16. Li HJ, Li X, Liu N, Zhang H, Truglio …

Characterization of the azinomycin B biosynthetic gene cluster

WitrynaIn this regard, we have identified naphthoate synthase (1,4-dihydroxy-2-naphthoyl-CoA synthase, EC: 4.1.3.36; DHNS) as an anti-E. faecalis target, as it is an essential … Witryna17 sty 2007 · The aerobic Gram-positive bacterium Geobacillus kaustophilus is a bacillus species that was isolated from deep-sea sediment from the Mariana Trench. 1,4-Dihydroxy-2-naphthoate (DHNA) synthetase plays a vital role in the biosynthesis of menaquinone (vitamin K 2) in this bacterium. DHNA synthetase from Geobacillus … rotary coring ground investigation

Biosynthesis of Vitamin K1 (Phylloquinone) by Plant

The enzyme 1,4-dihydroxy-2-naphthoyl-CoA synthase (EC 4.1.3.36) catalyzes the sixth step in the biosynthesis of phylloquinone and menaquinone, the two forms of vitamin K. In E. coli, 1,4-dihydroxy-2-naphthoyl-CoA synthase, formerly known as naphthoate synthase, is encoded by menB and uses O … Zobacz więcej MenB is part of the crotonase fold super family, named after the crotonase fold in their structure. The systematic name for MenB is 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA dehydratase (cyclizing). Other common … Zobacz więcej MenB is composed of two hexamers in an asymmetric unit, these hexamers are each composed of two trimers in an eclipsed arrangement. Each sub unit of the hexamers has three C terminal alpha helices, and a N terminal spiral core. These sub units come … Zobacz więcej MenB does not require any cofactors to catalyze the reaction. In the organism Escherichia coli three inhibitors exist: 1-hydroxy-2-naphthoyl-CoA, 2,3-dihydroxybenzoyl-CoA, and 2,4-dihydroxybenzoyl-CoA. Zobacz więcej It was originally thought that the product of this reaction had an oxygen where the SCoA currently resides, however; new research has shown that MenB only catalyzes the … Zobacz więcej Homologous genes MenB exist in many different organisms, such as; Galium mollugo, Geobacillus kaustophilus, MenB is only … Zobacz więcej WitrynaIn this regard, we have identified naphthoate synthase (1,4‐dihydroxy‐2‐naphthoyl‐CoA synthase, EC: 4.1.3.36; DHNS) as an anti‐E. faecalis target, as it is an essential … Witryna13 kwi 2024 · Changes in gene expression by q-RT-PCR analysis at different stages in menaquinone and mevalonate pathway biosynthesis: A MenA,1,4-dihydroxy-2-naphthoate octaprenyltransferase, MenB, naphthoate synthase, MenC, osuccinylbenzoate-CoA synthase, MenD, 2-succinyl-6- hydroxy-2,4-cyclohexadiene … stoughton wi death notices