Web27 aug. 2024 · l -Buthionine sulfoximine ( l -BSO) is an adjuvant drug that is reported to increase the sensitivity of cancer cells to neoplastic agents. Dendrimers are exceptional …
Inhibition of Glutathione and Thioredoxin Metabolism Enhances
Web19 jul. 2011 · L-Buthionine-sulfoximine (BSO) is a sulfoximine used in chemotherapy, which irreversibly inhibits g-glutamylcysteine synthetase, thereby depleting cells of glutathione (GSH), a metabolite that plays a critical role in protecting cells against oxidative stress and resulting in free radical-induced apoptosis. Web30 jun. 2016 · Objective: To study the effects of BSO, GSH, Vit-C and DMPS on the nephrotoxicity of mercury. Methods: The rats in groups 1, 2 and 3 were sc injected with … high oaks east richardson texas
Glutathione depletion by buthionine sulfoximine induces DNA …
Web31 mrt. 2024 · Importantly, this multifunctional hydrogel significantly promoted the proliferation of normal skin cells and accelerated the bacteria-infected wound healing by the effective chemo-sonodynamic antibacterial activity and the enhanced angiogenesis. WebL-Buthionine-sulfoximine ≥97% (TLC) Synonym (s): L-BSO Empirical Formula (Hill Notation): C8H18N2O3S CAS Number: 83730-53-4 Molecular Weight: 222.31 Beilstein: … Web20 aug. 2024 · L-Buthionine (S,R)–Sulfoximine (BSO) treatment was performed as previously described [ 24 ]. 2.4. Plasmids and siRNAs The 3 × Flag-SNAP47 construct was generated by cloning SNAP47 into the multiple cloning site of p3 × Flag-CMV10 vector with KpnI/BamHI enzymes. The primers used to amplify SNAP47 are shown in Table 1. high oaks farm calthwaite