WebImmunocytochemistry for PTEN, b-Catenin, and p53 The endogenous peroxidase activity was blocked with 3% hydrogen peroxide for 30 minutes at room temperature. The heat-induced antigen retrieval step for PTEN was performed for 15 minutes in 0.01 M ethylenediamine tetraacetic acid, pH 8.0, by using an autoclave; antigen retrieval for b … WebJul 19, 2024 · Recently, we demonstrated that GRWD1 is a novel oncogene . 4 We previously found that GRWD1 is overexpressed in cancer cells. 69 In a recent paper, we …
GRWD1 directly interacts with p53 and negatively regulates p53 ...
WebApr 13, 2024 · GEO help: Mouse over screen elements for information. A recurrently amplified long noncoding RNA in colorectal cancer regulates p53 protein stability through GRWD1/RPL11/MDM2 axis [RNA-seq] By integrating genome-wide copy number alteration, RNA-seq and proteomics data from 589 colorectal cancer (CRC) patients, we revealed … WebGRWD1 is a novel negative regulator of p53 and a potential oncogene, and its effects are mediated by the N‐terminal region of GRWD1, including the acidic domain. The … gtha area
P53-positive expression in dysplastic surgical margins is a …
WebGlutamate-rich WD40 repeat-containing 1 (GRWD1) is a Cdt1- binding protein that promotes mini-chromosome maintenance (MCM) loading through its histone chaperone activity. GRWD1 acts as a tumor-promoting factor by downregulating p53 (also known as TP53) via the RPL11-MDM2-p53 axis. WebScale bar, 50 mm. (E) The levels of p53 protein were determined in HCT116 p53 +/+ and HCT116 p53 -/-tumors treated with and without 5-FU. Source publication +1 Long noncoding RNA PiHL... WebObjective To explore the origin of ovarian high grade serous carcinoma (HGSC) through analysing the expression and significance of PAX8, PAX2, p53 and RAS in the ovary and fallopian tube of different types and grades of serous carcinoma. Methods A total of 44 cases tissue samples of ovarian tumor including 34 malignant ovarian tumor and 10 … find branch name from ifsc